| Acute myeloblastic leukemia with maturation | |
|---|---|
| Classification and external resources | |
Myeloblast |
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| ICD-O: | M9874/3 |
| MeSH | D015470 |
M2 is a subtype of AML (Acute Myeloid Leukemia).
It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.
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